Current status and perspectives of patient-derived xenograft models in cancer research
نویسندگان
چکیده
Cancers remain a major public health problem worldwide, which still require profound research in both the basic and preclinical fields. Patient-derived xenograft (PDX) models are created when cancerous cells or tissues from patients' primary tumors are implanted into immunodeficient mice to simulate human tumor biology in vivo, which have been extensively used in cancer research. The routes of implantation appeared to affect the outcome of PDX research, and there has been increasing applications of patient-derived orthotopic xenograft (PDOX) models. In this review, we firstly summarize the methodology to establish PDX models and then go over recent application and function of PDX models in basic cancer research on the areas of cancer characterization, initiation, proliferation, metastasis, and tumor microenvironment and in preclinical explorations of anti-cancer targets, drugs, and therapeutic strategies and finally give our perspectives on the future prospects of PDX models.
منابع مشابه
Tumorigenicity of Esophageal Cancer Stem Cells (ECSCs) in nude mouse xenograft model
Background and objectives: Modeling cancer in vivo is a very important tool to investigate cancer pathogenesis and molecular mechanisms involved in cancer progression. Laboratory mice are the most common animal used for rebuilding human cancer in vivo. Cancer stem cells (CSCs) are the main reason of failure in cancer therapy because of tumor relapse and metastasis. Isolation of cancer stem cell...
متن کاملایجاد مدل زنوگرافت بومی تومور ویلمز در ایران و کاربردهای آن در توسعه مطالعات پیش بالینی
Background : Wilms' tumor (nephroblastoma) is the most common renal malignancy of childhood. This cancer is considered as an embryonal neoplasm that arises from nephrogenic blastemal. Despite advances in therapeutic success, survival rate is still not satisfactory in tumors with unfavorable histology and recurrent cases. On the other hand, late adverse effects of chemotherapy threaten the lif...
متن کاملمطالعه میزان آنژیوژنز مدلهای زنوگرافت بومی گلیوبلاستوما مالتیفورم در بیماران ایرانی بهروش MVD-CD34
Background: Despite advances in cancer diagnosis and treatment, survival rate of patients suffering from glioblastoma multiform (GBM) has not been significantly improved. Therefore, novel therapeutic adjuncts to routine therapies have been suggested over time. Inhibition of angiogenesis by antiangiogenic drugs is one of the new approaches to inhibit the growth of malignant cells. Microvessel d...
متن کاملHuman 3-D tissue models in radiation biology: current status and future perspectives
In this review, we discuss the use of a variety of 3-D models (particularly 3-D skin, lung, breast and endothelial) in radiobiological research and highlight the differences in responses compared to 2-D culturing conditions (monolayers). We review the characteristics of existing 3-D models and aim to point out the substantial advantages 3-D cultures provide for modern radiobiology. In particula...
متن کاملUse of patient-derived xenograft mouse models in cancer research and treatment
Background of patient-derived xenograft mouse models Since most advanced cancers are still incurable, basic, preclinical and clinical cancer research remains necessary for developing new therapeutic modalities. Many cancer cell lines have been developed, which have for a long time been available for use in basic and preclinical cancer research. However, those cell lines have the disadvantage th...
متن کامل